Home Health & Fitness The cytokine storm

The cytokine storm

Covid-19 is caused by a strain of coronavirus known as Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). It has become a global pandemic that has impacted the lives of many people.Studies have shown that SARS-CoV-2 shares many biological features with SARS-CoV, a virus that was the reason of the 2002 outbreak of SARS, including the system of cell entry that is triggered by holding together the viral spike protein to angiotensin-converting enzyme 2. Studies have also spoken of a link between Covid-19 and cardiovascular problems. Pre-existing cardiovascular diseases seem to be linked with worsening of outcomes and in increased death risk in patients with Covid-19. However, Covid-19 itself can also induce myocardial injury, arrhythmia, acute coronary syndrome, and venous thromboembolism.SARS-CoV-2 is a member of the genus Betacoronavirus like the two other coronaviruses that have caused pandemic diseases (severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV)). As with SARS-CoV and MERS-CoV, SARS-CoV-2 causes a respiratory infection, which leads to viral pneumonia and acute respiratory distress syndrome (ARDS) in some patients.However, in addition to respiratory symptoms, uncontrolled SARS-CoV-2 infection can trigger a cytokine storm, whereby pro-inflammatory cytokines and chemokines are overproduced by the immune system, resulting in multi-organ damage. Furthermore, Covid-19 causes coagulation abnormalities in a substantial proportion of patients, which can lead to thromboembolic events.Pathogenic considerationsSARS-CoV-2 is caused by a novel enveloped RNA beta-coronavirus. Direct myocardial injury due to SARS-CoV-2 enters the human cells by binding to angiotensin-converting enzyme 2 (ACE2), a membrane bound aminopeptidase which is highly expressed in the heart and lungs. ACE2 plays an important role in neurohumoral regulation of CV system in normal health as well as in various disease conditions. The binding of SARS-CoV-2 to ACE2 can result in alteration of ACE2 signalling pathways, leading to acute myocardial and lung injury.Systemic inflammation: More severe forms of Covid-19 are characterised by acute systemic inflammatory response and cytokine storm, which can result in injury to multiple organs leading to multiorgan failure. Studies have shown high circulatory levels of pro-inflammatory cytokines in patients with severe/critical Covid-19.Altered myocardial demand-supply ratio: Increased cardiometabolic demand associated with the systemic infection coupled with hypoxia caused by acute respiratory illness can impair myocardial oxygen demand-supply relationship and lead to acute myocardial injury.Plaque rupture and coronary thrombosis: Systemic inflammation as well as increased stress due to increased coronary blood flow can precipitate plaque rupture resulting in acute myocardial infarction. Prothrombotic milieu created by systemic inflammation further increases the risk. Adverse effects of various therapies: Various antiviral drugs, corticosteroids and other therapies aimed at treating Covid-19 can also have deleterious effects on the CV system.Electrolyte imbalances: Electrolyte imbalances can occur in any critical systemic illness and precipitate arrhythmias, especially in patients with underlying cardiac disorder. There is particular concern about hypokalemia in Covid-19, due to interaction of SARS-CoV-2 with renin-angiotensin-aldosterone system. Hypokalemia increases vulnerability to various tachyarrhythmias.Although respiratory illness is the dominant clinical manifestation of Covid-19, the sheer burden of the illness implies that a large number of patients with Covid-19 would present with pre-existing CVD or cardiovascular diseases or develop new-onset cardiac dysfunction during the course of the illness. Considering this, the current understanding about the interplay between CVD and Covid-19 is grossly inadequate. It is therefore highly desirable that the future studies on Covid-19 specifically describe the incidence, mechanisms, clinical presentation and outcomes of various CVD manifestations in these patients. The diagnostic and therapeutic challenges posed by the concurrence of these two illnesses also need to be adequately studied.(The author is an interventional cardiologist)
Read More

LEAVE A REPLY

Please enter your comment!
Please enter your name here

- Advertisment -

Most Popular

How can I tell the difference between the flu and COVID-19?

Last Updated : Oct 01, 2020 01:54 PM IST | Source: AP Body aches, sore throat, fever, cough, shortness of breath, fatigue and headaches are symptoms shared by the two. How can I tell the difference between the flu and COVID-19?It’s impossible to tell without a test. Influenza and COVID-19 have such similar symptoms, you…

Cardiac arrest common in sick Covid-19 patients

Photo for representational purpose only. iStock New York, October 1 Cardiac arrest is common in critically ill patients with Covid-19 and is associated with poor survival, particularly among patients aged 80 or older, say researchers. The findings, published in the journal The BMJ, could help guide end-of-life care discussions with critically ill patients with Covid-19…

Beware: Vitamin D deficiency can make you obese and lead to stunted growth

Vitamin D, or the ‘Sunshine Vitamin as it is also known as, is one of the essential nutrients that makes your bones and teeth stronger, wards off infections and diseases and keeps you cheerful. This fat-soluble vitamin can also bring down your risk of cancer, autoimmune diseases, heart disease and diabetes. But unfortunately, as many…

COVID-19 cases decline, deaths increase in Chandigarh as September ends

Naina MishraTribune News ServiceChandigarh, October 1 As September comes to an end, the Union Territory has started to witness a decline in the number of positive COVID-19 cases, and daily tests.  However, COVID deaths have increased with every passing week.  September has recorded 100 COVID-19 deaths whereas August reported only 39 deaths.  At least three…

Recent Comments